Image-guided neural activity manipulation with a paramagnetic drug

Sarah Bricault; Ali Barandov; Peter Harvey; Elizabeth DeTienne; Aviad Hai; Alan Jasanoff

doi:10.1038/s41467-019-13933-5

Nature Communications (Jan 2020)

Image-guided neural activity manipulation with a paramagnetic drug

Sarah Bricault,
Ali Barandov,
Peter Harvey,
Elizabeth DeTienne,
Aviad Hai,
Alan Jasanoff

Affiliations

Sarah Bricault: Department of Biology, Massachusetts Institute of Technology
Ali Barandov: Department of Biological Engineering, Massachusetts Institute of Technology
Peter Harvey: Department of Biological Engineering, Massachusetts Institute of Technology
Elizabeth DeTienne: Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology
Aviad Hai: Department of Biological Engineering, Massachusetts Institute of Technology
Alan Jasanoff: Department of Biological Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-019-13933-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 6

Abstract

Read online

Targeted manipulations of neural activity in the living brain remain a significant challenge. In this study the authors introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal