Nature Communications (May 2021)
Actuation enhances patterning in human neural tube organoids
- Abdel Rahman Abdel Fattah,
- Brian Daza,
- Gregorius Rustandi,
- Miguel Ángel Berrocal-Rubio,
- Benjamin Gorissen,
- Suresh Poovathingal,
- Kristofer Davie,
- Jorge Barrasa-Fano,
- Mar Cóndor,
- Xuanye Cao,
- Derek Hadar Rosenzweig,
- Yunping Lei,
- Richard Finnell,
- Catherine Verfaillie,
- Maurilio Sampaolesi,
- Peter Dedecker,
- Hans Van Oosterwyck,
- Stein Aerts,
- Adrian Ranga
Affiliations
- Abdel Rahman Abdel Fattah
- Laboratory of Bioengineering and Morphogenesis, Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Brian Daza
- Laboratory of Bioengineering and Morphogenesis, Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Gregorius Rustandi
- Laboratory of Bioengineering and Morphogenesis, Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Miguel Ángel Berrocal-Rubio
- Laboratory of Bioengineering and Morphogenesis, Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Benjamin Gorissen
- J.A.Paulson School of Engineering and Applied Sciences, Harvard University
- Suresh Poovathingal
- Center for Brain & Disease Research, VIB-KU Leuven
- Kristofer Davie
- Center for Brain & Disease Research, VIB-KU Leuven
- Jorge Barrasa-Fano
- Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Mar Cóndor
- Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Xuanye Cao
- Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine
- Derek Hadar Rosenzweig
- Division of Experimental Surgery, McGill University
- Yunping Lei
- Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine
- Richard Finnell
- Center for Precision Environmental Health, Departments of Molecular and Human Genetics, Molecular and Cellular Biology and Medicine, Baylor College of Medicine
- Catherine Verfaillie
- Stem Cell and Developmental Biology, Departments of Development and Regeneration, KU Leuven
- Maurilio Sampaolesi
- Laboratory of Translational Cardiomyology, Department of Development and Regeneration, Stem Cell Institute, KU Leuven
- Peter Dedecker
- Laboratory for Nanobiology, Biochemistry, Molecular and Structural Biology Division, Department of Chemistry, KU Leuven
- Hans Van Oosterwyck
- Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- Stein Aerts
- Center for Brain & Disease Research, VIB-KU Leuven
- Adrian Ranga
- Laboratory of Bioengineering and Morphogenesis, Biomechanics Section, Department of Mechanical Engineering, KU Leuven
- DOI
- https://doi.org/10.1038/s41467-021-22952-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Mechanical forces, along with gene regulatory networks and cell-cell signalling, play an important role in the complex organization of tissues. Here the authors describe devices that actively apply mechanical force to developing neural tube, demonstrating that mechanical forces increase growth and enhance patterning.
