Carbazole Alkaloids from <i>Clausena anisum-olens</i>: Isolation, Characterization, and Anti-HIV Evaluation

Jing-Hua Yang; Xin-Yi Wang; Yi-Ping Zhou; Rong Lu; Chin-Ho Chen; Meng-Han Zhang; Yung-Yi Cheng; Susan  L. Morris-Natschke; Kuo-Hsiung Lee; Yun-Song Wang

doi:10.3390/molecules25010099

Molecules (Dec 2019)

Carbazole Alkaloids from <i>Clausena anisum-olens</i>: Isolation, Characterization, and Anti-HIV Evaluation

Jing-Hua Yang,
Xin-Yi Wang,
Yi-Ping Zhou,
Rong Lu,
Chin-Ho Chen,
Meng-Han Zhang,
Yung-Yi Cheng,
Susan L. Morris-Natschke,
Kuo-Hsiung Lee,
Yun-Song Wang

Affiliations

Jing-Hua Yang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Xin-Yi Wang: The High School Affiliated to Yunnan Normal University, Kunming 650106, China
Yi-Ping Zhou: School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Rong Lu: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Chin-Ho Chen: Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Meng-Han Zhang: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Yung-Yi Cheng: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Susan L. Morris-Natschke: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Kuo-Hsiung Lee: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Yun-Song Wang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China

DOI: https://doi.org/10.3390/molecules25010099
Journal volume & issue: Vol. 25, no. 1
p. 99

Abstract

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Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3−8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1−8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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