Carbazole Alkaloids from <i>Clausena anisum-olens</i>: Isolation, Characterization, and Anti-HIV Evaluation
Jing-Hua Yang,
Xin-Yi Wang,
Yi-Ping Zhou,
Rong Lu,
Chin-Ho Chen,
Meng-Han Zhang,
Yung-Yi Cheng,
Susan L. Morris-Natschke,
Kuo-Hsiung Lee,
Yun-Song Wang
Affiliations
Jing-Hua Yang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Xin-Yi Wang
The High School Affiliated to Yunnan Normal University, Kunming 650106, China
Yi-Ping Zhou
School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Rong Lu
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Chin-Ho Chen
Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Meng-Han Zhang
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Yung-Yi Cheng
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Susan L. Morris-Natschke
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Kuo-Hsiung Lee
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Yun-Song Wang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3−8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1−8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
