Nature Communications (Jan 2020)

Structural basis of proton-coupled potassium transport in the KUP family

  • Igor Tascón,
  • Joana S. Sousa,
  • Robin A. Corey,
  • Deryck J. Mills,
  • David Griwatz,
  • Nadine Aumüller,
  • Vedrana Mikusevic,
  • Phillip J. Stansfeld,
  • Janet Vonck,
  • Inga Hänelt

DOI
https://doi.org/10.1038/s41467-020-14441-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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KUP transporters facilitate potassium uptake by the co-transport of protons and are key players in potassium homeostasis. Here authors identify the potassium importer KimA from Bacillus subtilis as a new member of the KUP transporter family and show the cryo-EM structure of KimA in an inward-occluded, trans-inhibited conformation.