Synthesis and biological evaluation of new benzofuran carboxamide derivatives

Abstract

A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(β-alanamido)-benzofuran-2-carboxamide derivatives (5a–o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging activities. The synthesized compounds were characterized by NMR, IR, Mass and X-ray crystallographic techniques.

Keywords

• Benzofuran
• Carboxamide
• Glycinamide
• β-Alanamide
• Anti-inflammatory
• Antimicrobial
• Antioxidant