Nature Communications (Nov 2020)
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
- Bryan C. Quach,
- Michael J. Bray,
- Nathan C. Gaddis,
- Mengzhen Liu,
- Teemu Palviainen,
- Camelia C. Minica,
- Stephanie Zellers,
- Richard Sherva,
- Fazil Aliev,
- Michael Nothnagel,
- Kendra A. Young,
- Jesse A. Marks,
- Hannah Young,
- Megan U. Carnes,
- Yuelong Guo,
- Alex Waldrop,
- Nancy Y. A. Sey,
- Maria T. Landi,
- Daniel W. McNeil,
- Dmitriy Drichel,
- Lindsay A. Farrer,
- Christina A. Markunas,
- Jacqueline M. Vink,
- Jouke-Jan Hottenga,
- William G. Iacono,
- Henry R. Kranzler,
- Nancy L. Saccone,
- Michael C. Neale,
- Pamela Madden,
- Marcella Rietschel,
- Mary L. Marazita,
- Matthew McGue,
- Hyejung Won,
- Georg Winterer,
- Richard Grucza,
- Danielle M. Dick,
- Joel Gelernter,
- Neil E. Caporaso,
- Timothy B. Baker,
- Dorret I. Boomsma,
- Jaakko Kaprio,
- John E. Hokanson,
- Scott Vrieze,
- Laura J. Bierut,
- Eric O. Johnson,
- Dana B. Hancock
Affiliations
- Bryan C. Quach
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Michael J. Bray
- Department of Psychiatry, Washington University
- Nathan C. Gaddis
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Mengzhen Liu
- Department of Psychology, University of Minnesota Twin Cities
- Teemu Palviainen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Camelia C. Minica
- Department of Biological Psychology, Vrije Universiteit
- Stephanie Zellers
- Department of Psychology, University of Minnesota Twin Cities
- Richard Sherva
- Department of Medicine (Biomedical Genetics), Boston University School of Medicine
- Fazil Aliev
- Department of Psychology, Virginia Commonwealth University
- Michael Nothnagel
- Cologne Center for Genomics, University of Cologne
- Kendra A. Young
- Department of Epidemiology, University of Colorado Anschutz Medical Campus
- Jesse A. Marks
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Hannah Young
- Department of Psychology, University of Minnesota Twin Cities
- Megan U. Carnes
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Yuelong Guo
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Alex Waldrop
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Nancy Y. A. Sey
- Department of Genetics, University of North Carolina at Chapel Hill
- Maria T. Landi
- Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services
- Daniel W. McNeil
- Department of Psychology, West Virginia University
- Dmitriy Drichel
- Cologne Center for Genomics, University of Cologne
- Lindsay A. Farrer
- Department of Medicine (Biomedical Genetics), Boston University School of Medicine
- Christina A. Markunas
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Jacqueline M. Vink
- Behavioural Science Institute, Radboud University
- Jouke-Jan Hottenga
- Department of Biological Psychology, Vrije Universiteit
- William G. Iacono
- Department of Psychology, University of Minnesota Twin Cities
- Henry R. Kranzler
- Department of Psychiatry, University of Pennsylvania Perelman School of Medicine
- Nancy L. Saccone
- Department of Genetics, Washington University
- Michael C. Neale
- Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University
- Pamela Madden
- Department of Psychiatry, Washington University
- Marcella Rietschel
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Mary L. Marazita
- Center for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh
- Matthew McGue
- Department of Psychology, University of Minnesota Twin Cities
- Hyejung Won
- Department of Genetics, University of North Carolina at Chapel Hill
- Georg Winterer
- Experimental & Clinical Research Center, Department of Anesthesiology and Operative Intensive Care Medicine, Charité - University Medicine Berlin
- Richard Grucza
- Departments of Family and Community Medicine and Health and Clinical Outcomes Research, Saint Louis University
- Danielle M. Dick
- Department of Psychology, Virginia Commonwealth University
- Joel Gelernter
- Department of Psychiatry, Yale University School of Medicine
- Neil E. Caporaso
- Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services
- Timothy B. Baker
- Center for Tobacco Research and Intervention, Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Dorret I. Boomsma
- Department of Biological Psychology, Vrije Universiteit
- Jaakko Kaprio
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- John E. Hokanson
- Department of Epidemiology, University of Colorado Anschutz Medical Campus
- Scott Vrieze
- Department of Psychology, University of Minnesota Twin Cities
- Laura J. Bierut
- Department of Psychiatry, Washington University
- Eric O. Johnson
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- Dana B. Hancock
- GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International
- DOI
- https://doi.org/10.1038/s41467-020-19265-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.
