SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory

Kimiko Shimizu; Yodai Kobayashi; Erika Nakatsuji; Maya Yamazaki; Shigeki Shimba; Kenji Sakimura; Yoshitaka Fukada

doi:10.1038/ncomms12926

Nature Communications (Sep 2016)

SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory

Kimiko Shimizu,
Yodai Kobayashi,
Erika Nakatsuji,
Maya Yamazaki,
Shigeki Shimba,
Kenji Sakimura,
Yoshitaka Fukada

Affiliations

Kimiko Shimizu: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Yodai Kobayashi: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Erika Nakatsuji: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Maya Yamazaki: Department of Cellular Neurobiology, Brain Research Institute, Niigata University
Shigeki Shimba: Department of Health Science, School of Pharmacology, Nihon University
Kenji Sakimura: Department of Cellular Neurobiology, Brain Research Institute, Niigata University
Yoshitaka Fukada: Department of Biological Sciences, Graduate School of Science, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms12926
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Learning and memory are subject to circadian variation, though the molecular mechanisms behind this are unclear. Here, the authors show SCOP, a regulator of hippocampal memory, undergoes circadian changes in CA1 membrane raft dynamics and contributes to time-dependent changes in long-term memory.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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