Effect of HM-Exos on the migration and inflammatory response of LPS-exposed dental pulp stem cells

Ehsaneh Azaryan; Samira Karbasi; Mansoore Saharkhiz; Mohammad Yahya Hanafi-Bojd; Asghar Zarban; Fariba Emadian Razavi; Mohsen Naseri

doi:10.1186/s12903-023-02796-4

BMC Oral Health (Feb 2023)

Effect of HM-Exos on the migration and inflammatory response of LPS-exposed dental pulp stem cells

Ehsaneh Azaryan,
Samira Karbasi,
Mansoore Saharkhiz,
Mohammad Yahya Hanafi-Bojd,
Asghar Zarban,
Fariba Emadian Razavi,
Mohsen Naseri

Affiliations

Ehsaneh Azaryan: Student Research Committee, Birjand University of Medical Sciences
Samira Karbasi: Department of Molecular Medicine, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences
Mansoore Saharkhiz: Department of Immunology, Faculty of Medicine, Birjand University of Medical Sciences
Mohammad Yahya Hanafi-Bojd: Cellular and Molecular Research Center, Birjand University of Medical Sciences
Asghar Zarban: Cardiovascular Diseases Research Center, Birjand University of Medical Sciences
Fariba Emadian Razavi: Dental Research Center, Faculty of Dentistry, Birjand University of Medical Sciences
Mohsen Naseri: Cellular and Molecular Research Center, Department of Molecular Medicine, Birjand University of Medical Sciences

DOI: https://doi.org/10.1186/s12903-023-02796-4
Journal volume & issue: Vol. 23, no. 1
pp. 1 – 9

Abstract

Read online

Highlights HM-Exos were successfully isolated using the exosome extraction kit. The size and shape of HM-Exos were analyzed using DLS, SEM, and TEM. HM-Exos improved the migration potential of LPS-exposed HDPSCs. HM-Exos reduced the expression of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in LPS-exposed HDPSCs.

Published in BMC Oral Health

ISSN: 1472-6831 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Dentistry
Website: http://bmcoralhealth.biomedcentral.com

About the journal

Abstract

Keywords