Nature Communications (Mar 2023)
Endothelial deletion of PTBP1 disrupts ventricular chamber development
- Hongyu Liu,
- Ran Duan,
- Xiaoyu He,
- Jincu Qi,
- Tianming Xing,
- Yahan Wu,
- Liping Zhou,
- Lingling Wang,
- Yujing Shao,
- Fulei Zhang,
- Huixing Zhou,
- Xingdong Gu,
- Bowen Lin,
- Yuanyuan Liu,
- Yan Wang,
- Yi Liu,
- Li Li,
- Dandan Liang,
- Yi-Han Chen
Affiliations
- Hongyu Liu
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Ran Duan
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Xiaoyu He
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Jincu Qi
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Tianming Xing
- Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine
- Yahan Wu
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Liping Zhou
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Lingling Wang
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Yujing Shao
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Fulei Zhang
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Huixing Zhou
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Xingdong Gu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine
- Bowen Lin
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Yuanyuan Liu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine
- Yan Wang
- Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine
- Yi Liu
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Li Li
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Dandan Liang
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- Yi-Han Chen
- Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-37409-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
Alternative splicing crucially affects various biological processes, however, its function in heart development is largely unknown. Here, the authors show an essential role of alternative splicing factor PTBP1 in ventricular chamber development.
