Performances of Functional and Anatomic Imaging Modalities in <i>Succinate Dehydrogenase A-</i>Related Metastatic Pheochromocytoma and Paraganglioma

Mayank Patel; Abhishek Jha; Alexander Ling; Clara C. Chen; Corina Millo; Mickey J. M. Kuo; Matthew A. Nazari; Sara Talvacchio; Kailah Charles; Markku Miettinen; Jaydira Del Rivero; Alice P. Chen; Naris Nilubol; Frank I. Lin; Ali Cahid Civelek; David Taïeb; Jorge A. Carrasquillo; Karel Pacak

doi:10.3390/cancers14163886

Cancers (Aug 2022)

Performances of Functional and Anatomic Imaging Modalities in <i>Succinate Dehydrogenase A-</i>Related Metastatic Pheochromocytoma and Paraganglioma

Mayank Patel,
Abhishek Jha,
Alexander Ling,
Clara C. Chen,
Corina Millo,
Mickey J. M. Kuo,
Matthew A. Nazari,
Sara Talvacchio,
Kailah Charles,
Markku Miettinen,
Jaydira Del Rivero,
Alice P. Chen,
Naris Nilubol,
Frank I. Lin,
Ali Cahid Civelek,
David Taïeb,
Jorge A. Carrasquillo,
Karel Pacak

Affiliations

Mayank Patel: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
Abhishek Jha: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
Alexander Ling: Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
Clara C. Chen: Nuclear Medicine Department, Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
Corina Millo: Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
Mickey J. M. Kuo: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
Matthew A. Nazari: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
Sara Talvacchio: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
Kailah Charles: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
Markku Miettinen: Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD 20814, USA
Jaydira Del Rivero: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Alice P. Chen: Early Clinical Trials Development Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Naris Nilubol: Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Frank I. Lin: Targeted Radionuclide Therapy Section, Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Ali Cahid Civelek: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD 21287, USA
David Taïeb: Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, 13273 Marseille, France
Jorge A. Carrasquillo: Targeted Radionuclide Therapy Section, Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Karel Pacak: Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA

DOI: https://doi.org/10.3390/cancers14163886
Journal volume & issue: Vol. 14, no. 16
p. 3886

Abstract

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The study identifies the importance of positron emission tomographic (PET) and anatomic imaging modalities and their individual performances in detecting succinate dehydrogenase A (SDHA)-related metastatic pheochromocytoma and paraganglioma (PPGL). The detection rates of PET modalities—68Ga-DOTATATE, 18F-FDG, and 18F-FDOPA—along with the combination of computed tomography (CT) and magnetic resonance imaging (MRI) are compared in a cohort of 11 patients with metastatic PPGL in the setting of a germline SDHA mutation. The imaging detection performances were evaluated at three levels: overall lesions, anatomic regions, and a patient-by-patient basis. 68Ga-DOTATATE PET demonstrated a lesion-based detection rate of 88.6% [95% confidence interval (CI), 84.3–92.5%], while 18F-FDG, 18F-FDOPA, and CT/MRI showed detection rates of 82.9% (CI, 78.0–87.1%), 39.8% (CI, 30.2–50.2%), and 58.2% (CI, 52.0–64.1%), respectively. The study found that 68Ga-DOTATATE best detects lesions in a subset of patients with SDHA-related metastatic PPGL. However, 18F-FDG did detect more lesions in the liver, mediastinum, and abdomen/pelvis anatomic regions, showing the importance of a combined approach using both PET modalities in evaluating SDHA-related PPGL.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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