Nature Communications (May 2017)

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

  • Nandhini Ponnuswamy,
  • Maartje M. C. Bastings,
  • Bhavik Nathwani,
  • Ju Hee Ryu,
  • Leo Y. T. Chou,
  • Mathias Vinther,
  • Weiwei Aileen Li,
  • Frances M. Anastassacos,
  • David J. Mooney,
  • William M. Shih

DOI
https://doi.org/10.1038/ncomms15654
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.