Synthesis and Adrenolytic Activity of New Propanolamines

Abstract

The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for a1-, a2- and β1-adrenoceptor binding affinity.

Keywords

• α1-andrenoceptor antagonist
• synthesis
• pharmacology