Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Zhennan Shi; Nathchar Naowarojna; Zijian Pan; Yilong Zou

doi:10.1038/s41467-021-25159-5

Nature Communications (Aug 2021)

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Zhennan Shi,
Nathchar Naowarojna,
Zijian Pan,
Yilong Zou

Affiliations

Zhennan Shi: Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
Nathchar Naowarojna: Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
Zijian Pan: School of Life Sciences, Westlake University
Yilong Zou: Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine

DOI: https://doi.org/10.1038/s41467-021-25159-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 4

Abstract

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The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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