Influence of pore structural properties in metal-organic frameworks on the host-guest interaction in drug delivery

Xiao-Wei Yan; Somayeh Tarasi; Su-Juan Wang; Kobra Rostamizadeh; Mao-Lin Hu; Ali Morsali; Ali Ramazani; Roghayeh Tarasi; Yavar Ahmadi

Arabian Journal of Chemistry (Aug 2023)

Influence of pore structural properties in metal-organic frameworks on the host-guest interaction in drug delivery

Xiao-Wei Yan,
Somayeh Tarasi,
Su-Juan Wang,
Kobra Rostamizadeh,
Mao-Lin Hu,
Ali Morsali,
Ali Ramazani,
Roghayeh Tarasi,
Yavar Ahmadi

Affiliations

Xiao-Wei Yan: Guangxi Key Laboratory of Health Care Food Science and Technology, College of Food and Bioengineering, Hezhou University, No. 18 West Ring Road, Hezhou, Guangxi 542899, China
Somayeh Tarasi: Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran, Iran
Su-Juan Wang: Guangxi Key Laboratory of Health Care Food Science and Technology, College of Food and Bioengineering, Hezhou University, No. 18 West Ring Road, Hezhou, Guangxi 542899, China
Kobra Rostamizadeh: Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Mao-Lin Hu: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China; Corresponding authors at: Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran (A. Ramazani); College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China (M. Hu).
Ali Morsali: Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran, Iran; Corresponding authors at: Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran (A. Ramazani); College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China (M. Hu).
Ali Ramazani: Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan 45371-38791, Iran; Department of Biotechnology, Research Institute of Modern Biological Techniques (RIMBT), University of Zanjan, Zanjan 45371-38791, Iran; Corresponding authors at: Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran (A. Ramazani); College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China (M. Hu).
Roghayeh Tarasi: Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Yavar Ahmadi: Department of Basic Sciences, Farhangian University, Tehran 1939614464, Iran

Journal volume & issue: Vol. 16, no. 8
p. 104887

Abstract

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Properties of pore structure in Metal-organic frameworks (MOFs) play a key role in the adsorption of target molecules hence are used to improve the efficiency in MOFs. In this study, we synthesized three MOFs with different hydrophilicity, namely TMU-6(RL1), TMU-21(RL2) and TMU-59. Additionally, we studied the effect of hydrophobicity/hydrophilicity of pore in MOFs on the drug delivery and sensing properties. The structure of these frameworks was characterized by XPS, BET, XRD, IR and TG. The DLC and DLE of TMU-6(RL1), TMU-21(RL2) and TMU-59, were determined by (20%, 70%), (18%, 78%) and (3.6%, 13.6%), respectively. Also, the curcumin release reached 74%, 57% and 8% respectively for TMU-6(RL1), TMU-21(RL2) and TMU-59 after 100 h in PBS solution with pH 7.2 respectively. The carriers showed high adsorption efficiency and controlled release. Adsorption of curcumin as an anticancer drug to the MOFs was done through multiple mechanisms such as Hostπ–πGuest interaction and HostN–H⋯OGuest hydrogen bonds. Also, studies of in vitro anticancer revealed that the cytotoxicity of the MOFs@Curcumin composites against HT-29 cancer cells in MOFs was more than free curcumin. The findings demonstrated that the changes in the hydrophilic properties of frameworks can specifically control the Host-Guest interactions, drug loading and its release.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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