Nature Communications (Dec 2020)
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype
- Yonghe Wu,
- Michael Fletcher,
- Zuguang Gu,
- Qi Wang,
- Barbara Costa,
- Anna Bertoni,
- Ka-Hou Man,
- Magdalena Schlotter,
- Jörg Felsberg,
- Jasmin Mangei,
- Martje Barbus,
- Ann-Christin Gaupel,
- Wei Wang,
- Tobias Weiss,
- Roland Eils,
- Michael Weller,
- Haikun Liu,
- Guido Reifenberger,
- Andrey Korshunov,
- Peter Angel,
- Peter Lichter,
- Carl Herrmann,
- Bernhard Radlwimmer
Affiliations
- Yonghe Wu
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Michael Fletcher
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Zuguang Gu
- Heidelberg Center for Personalized Oncology (DKFZ-HIPO)
- Qi Wang
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Barbara Costa
- Division of Signal Transduction and Growth Control, DKFZ/ZMBH Alliance
- Anna Bertoni
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Ka-Hou Man
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Magdalena Schlotter
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Jörg Felsberg
- Medical Faculty, Institute of Neuropathology, Heinrich Heine University
- Jasmin Mangei
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Martje Barbus
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Ann-Christin Gaupel
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Wei Wang
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Tobias Weiss
- Department of Neurology and Brain Tumor Center, University Hospital Zurich
- Roland Eils
- Heidelberg Center for Personalized Oncology (DKFZ-HIPO)
- Michael Weller
- Department of Neurology and Brain Tumor Center, University Hospital Zurich
- Haikun Liu
- Division of Molecular Neurogenetics, DKFZ-ZMBH Alliance
- Guido Reifenberger
- Medical Faculty, Institute of Neuropathology, Heinrich Heine University
- Andrey Korshunov
- Department of Neuropathology, University of Heidelberg
- Peter Angel
- Division of Signal Transduction and Growth Control, DKFZ/ZMBH Alliance
- Peter Lichter
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Carl Herrmann
- Health Data Science Unit, Medical Faculty Heidelberg
- Bernhard Radlwimmer
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-020-20225-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesenchymal phenotype and promotes tumour progression.
