Communications Biology (Nov 2022)
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
- Maria Esteban-Lopez,
- Kenneth J. Wilson,
- Courtney Myhr,
- Elena M. Kaftanovskaya,
- Mark J. Henderson,
- Noel T. Southall,
- Xin Xu,
- Amy Wang,
- Xin Hu,
- Elena Barnaeva,
- Wenjuan Ye,
- Emmett R. George,
- John T. Sherrill,
- Marc Ferrer,
- Roy Morello,
- Irina U. Agoulnik,
- Juan J. Marugan,
- Alexander I. Agoulnik
Affiliations
- Maria Esteban-Lopez
- Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University
- Kenneth J. Wilson
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Courtney Myhr
- Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University
- Elena M. Kaftanovskaya
- Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University
- Mark J. Henderson
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Noel T. Southall
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Xin Xu
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Amy Wang
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Xin Hu
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Elena Barnaeva
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Wenjuan Ye
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Emmett R. George
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- John T. Sherrill
- Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences
- Marc Ferrer
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Roy Morello
- Department of Physiology & Cell Biology, University of Arkansas for Medical Sciences
- Irina U. Agoulnik
- Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University
- Juan J. Marugan
- Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health
- Alexander I. Agoulnik
- Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University
- DOI
- https://doi.org/10.1038/s42003-022-04143-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
