PLoS ONE (Jan 2019)

Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.

  • Jordânia M O Freire,
  • Hellíada V Chaves,
  • Alrieta H Teixeira,
  • Luzia Herminia T de Sousa,
  • Isabela Ribeiro Pinto,
  • José Jackson do N Costa,
  • Nayara Alves de Sousa,
  • Karuza Maria A Pereira,
  • Virgínia C C Girão,
  • Vanessa C S Ferreira,
  • João Evangelista de Ávila Dos Santos,
  • Mary Anne S Lima,
  • Antônia T A Pimenta,
  • Raquel de C Montenegro,
  • Maria Elisabete A de Moraes,
  • Vicente de P T Pinto,
  • Gerardo C Filho,
  • Mirna M Bezerra

DOI
https://doi.org/10.1371/journal.pone.0223800
Journal volume & issue
Vol. 14, no. 11
p. e0223800

Abstract

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Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received (per os) P. floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P. floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P. floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.