Nature Communications (May 2022)
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries
- Jan O. Kaufmann,
- Julia Brangsch,
- Avan Kader,
- Jessica Saatz,
- Dilyana B. Mangarova,
- Martin Zacharias,
- Wolfgang E. Kempf,
- Timm Schwaar,
- Marco Ponader,
- Lisa C. Adams,
- Jana Möckel,
- Rene M. Botnar,
- Matthias Taupitz,
- Lars Mägdefessel,
- Heike Traub,
- Bernd Hamm,
- Michael G. Weller,
- Marcus R. Makowski
Affiliations
- Jan O. Kaufmann
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Julia Brangsch
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Avan Kader
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Jessica Saatz
- Federal Institute for Materials Research and Testing (BAM), Division 1.1 Inorganic Trace Analysis
- Dilyana B. Mangarova
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Martin Zacharias
- Center of Functional Protein Assemblies, Technische Universität München (TUM)
- Wolfgang E. Kempf
- Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM)
- Timm Schwaar
- Federal Institute for Materials Research and Testing (BAM), Division 1.0 SAFIA Technologies
- Marco Ponader
- Federal Institute for Materials Research and Testing (BAM), Division 1.5 Protein Analysis
- Lisa C. Adams
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Jana Möckel
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Rene M. Botnar
- King’s College London, School of Biomedical Engineering and Imaging Sciences
- Matthias Taupitz
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Lars Mägdefessel
- Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM)
- Heike Traub
- Federal Institute for Materials Research and Testing (BAM), Division 1.1 Inorganic Trace Analysis
- Bernd Hamm
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Michael G. Weller
- Federal Institute for Materials Research and Testing (BAM), Division 1.5 Protein Analysis
- Marcus R. Makowski
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- DOI
- https://doi.org/10.1038/s41467-022-30464-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo prediction of aneurysm and rupture.
