Angiogenesis-Related Immune Signatures Correlate With Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity in Hepatocellular Carcinoma

Yuan Yang; Yuan Yang; Yuan Yang; Guozhi Wu; Guozhi Wu; Guozhi Wu; Qiang Li; Qiang Li; Ya Zheng; Ya Zheng; Min Liu; Min Liu; Lingshan Zhou; Lingshan Zhou; Lingshan Zhou; Zhaofeng Chen; Zhaofeng Chen; Yuping Wang; Yuping Wang; Qinghong Guo; Qinghong Guo; Rui Ji; Rui Ji; Yongning Zhou; Yongning Zhou

doi:10.3389/fmolb.2021.690206

Frontiers in Molecular Biosciences (Jun 2021)

Angiogenesis-Related Immune Signatures Correlate With Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity in Hepatocellular Carcinoma

Yuan Yang,
Yuan Yang,
Yuan Yang,
Guozhi Wu,
Guozhi Wu,
Guozhi Wu,
Qiang Li,
Qiang Li,
Ya Zheng,
Ya Zheng,
Min Liu,
Min Liu,
Lingshan Zhou,
Lingshan Zhou,
Lingshan Zhou,
Zhaofeng Chen,
Zhaofeng Chen,
Yuping Wang,
Yuping Wang,
Qinghong Guo,
Qinghong Guo,
Rui Ji,
Rui Ji,
Yongning Zhou,
Yongning Zhou

Affiliations

Yuan Yang: The First Clinical Medical College, Lanzhou University, Lanzhou, China
Yuan Yang: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Yuan Yang: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Guozhi Wu: The First Clinical Medical College, Lanzhou University, Lanzhou, China
Guozhi Wu: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Guozhi Wu: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Qiang Li: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Qiang Li: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Ya Zheng: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Ya Zheng: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Min Liu: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Min Liu: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Lingshan Zhou: The First Clinical Medical College, Lanzhou University, Lanzhou, China
Lingshan Zhou: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Lingshan Zhou: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Zhaofeng Chen: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Zhaofeng Chen: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Yuping Wang: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Yuping Wang: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Qinghong Guo: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Qinghong Guo: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Rui Ji: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Rui Ji: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
Yongning Zhou: Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
Yongning Zhou: Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China

DOI: https://doi.org/10.3389/fmolb.2021.690206
Journal volume & issue: Vol. 8

Abstract

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Background: Hepatocellular carcinoma (HCC) is one of the highly heterogeneous cancers that lacks an effective risk model for prognosis prediction. Therefore, we searched for angiogenesis-related immune genes that affected the prognosis of HCC to construct a risk model and studied the role of this model in HCC.Methods: In this study, we collected the transcriptome data of HCC from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) database. Pearson correlation analysis was performed to identify the association between immune genes and angiogenesis-related genes. Consensus clustering was applied to divide patients into clusters A and B. Subsequently, we studied the differentially expressed angiogenesis-related immune genes (DEari-genes) that affected the prognosis of HCC. The most significant features were identified by least absolute shrinkage and selection operator (LASSO) regression, and a risk model was constructed. The reliability of the risk model was evaluated in the TCGA discovery cohort and the ICGC validation cohort. In addition, we compared the novel risk model to the previous models based on ROC analysis. ssGSEA analysis was used for function evaluation, and pRRophetic was utilized to predict the sensitivity of administering chemotherapeutic agents.Results: Cluster A patients had favorable survival rates. A total of 23 DEari-genes were correlated with the prognosis of HCC. A five-gene (including BIRC5, KITLG, PGF, SPP1, and SHC1) signature-based risk model was constructed. After regrouping the HCC patients by the median score, we could effectively discriminate between them based on the adverse survival outcome, the unique tumor immune microenvironment, and low chemosensitivity.Conclusion: The five-gene signature-based risk score established by ari-genes showed a promising clinical prediction value.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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