Advances in Cancer Treatment by Targeting the Neddylation Pathway

Wenbin Gai; Zhiqiang Peng; Cui Hua Liu; Lingqiang Zhang; Lingqiang Zhang; Lingqiang Zhang; Hong Jiang

doi:10.3389/fcell.2021.653882

Frontiers in Cell and Developmental Biology (Apr 2021)

Advances in Cancer Treatment by Targeting the Neddylation Pathway

Wenbin Gai,
Zhiqiang Peng,
Cui Hua Liu,
Lingqiang Zhang,
Lingqiang Zhang,
Lingqiang Zhang,
Hong Jiang

Affiliations

Wenbin Gai: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, School of Basic Medicine, Medical College, Qingdao University, Qingdao, China
Zhiqiang Peng: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China
Cui Hua Liu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Lingqiang Zhang: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, School of Basic Medicine, Medical College, Qingdao University, Qingdao, China
Lingqiang Zhang: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China
Lingqiang Zhang: Peixian People’s Hospital, Xuzhou, China
Hong Jiang: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, School of Basic Medicine, Medical College, Qingdao University, Qingdao, China

DOI: https://doi.org/10.3389/fcell.2021.653882
Journal volume & issue: Vol. 9

Abstract

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Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the progression of various tumors, and MLN4924, which inhibits NEDD8-activating enzyme (NAE), is a promising new antitumor compound for combination therapy. Here, we summarize the latest progress in anticancer strategies targeting the neddylation pathway and their combined applications, providing a theoretical reference for developing antitumor drugs and combination therapies.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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