Bioactive Bis(indole) Alkaloids from a <i>Spongosorites</i> sp. Sponge

Abstract

Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.

Keywords

• <i>Spongosorites</i> sp. sponge
• bis(indole) alkaloids
• spongosoritins
• spongocarbamides
• topsentin
• sortase A inhibition