A new megastigmane from fresh roots of Rehmannia glutinosa

Abstract

A new megastigmane, rehmamegastigmane (1), together with eighteen known compounds lariciresinol (2), lariciresinol-4′-O-β-d-glucopyranoside (3), hierochin D (4), yemuoside YM1 (5), darendoside B (6), decaffeoylacteoside (7), jionoside B1 (8), catalpol (9), ajugol (10), 6-O-vanilloylajugol (11), 6-O-E-feruloylajugol (12), rehmapicroside (13), rehmapicrogenin (14), 3-methoxy-2,6,6-trimethylcyclohexane-1-enecarboxylic acid (15), vanillic acid (16), hydroferulic acid (17), threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol (18), p-hydroxyphenylethyl alcohol (19) was isolated from the fresh roots of Rehmannia glutinosa. Compounds 2–6 and 16–18 were isolated from this plant for the first time.

Keywords

• Scrophulariaceae
• Rehmannia glutinosa
• Chemical constituents
• Iridoids