Cancer Cell International (Apr 2005)

Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells

  • Shehata Marlene F

DOI
https://doi.org/10.1186/1475-2867-5-10
Journal volume & issue
Vol. 5, no. 1
p. 10

Abstract

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Abstract Cervical cancer is considered a common yet preventable cause of death in women. It has been estimated that about 420 women out of the 1400 women diagnosed with cervical cancer will die during 5 years from diagnosis. This review addresses the pathogenesis of cervical cancer in humans with a special emphasis on the human papilloma virus as a predominant cause of cervical cancer in humans. The current understanding of apoptosis and regulators of apoptosis as well as their implication in carcinogenesis will follow. A special focus will be given to the role of Rel/NF-κB family of genes in the growth and chemotherapeutic treatment of the malignant HeLa cervical cells emphasizing on Xrel3, a cRel homologue.

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