Nature Communications (Sep 2021)

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms

  • Janeri Fröberg,
  • Joshua Gillard,
  • Ria Philipsen,
  • Kjerstin Lanke,
  • Joyce Rust,
  • Diana van Tuijl,
  • Karina Teelen,
  • Teun Bousema,
  • Elles Simonetti,
  • Christa E. van der Gaast-de Jongh,
  • Mariska Bos,
  • Frank J. van Kuppeveld,
  • Berend-Jan Bosch,
  • Marrigje Nabuurs-Franssen,
  • Nannet van der Geest-Blankert,
  • Charlotte van Daal,
  • Martijn A. Huynen,
  • Marien I. de Jonge,
  • Dimitri A. Diavatopoulos

DOI
https://doi.org/10.1038/s41467-021-25949-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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There has been limited research on the role of the mucosal immune response to SARS-CoV-2 infection. Here, the authors perform a prospective observational household study and find that mucosal antibody responses are associated with decreased viral load and faster resolution of systemic symptoms.