Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

Devy Deliyanti; Dean M. Talia; Tong Zhu; Mhairi J. Maxwell; Alex Agrotis; Jack R. Jerome; Emily M. Hargreaves; Steven Gerondakis; Margaret L. Hibbs; Fabienne Mackay; Jennifer L. Wilkinson-Berka

doi:10.1038/s41467-017-00751-w

Nature Communications (Sep 2017)

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

Devy Deliyanti,
Dean M. Talia,
Tong Zhu,
Mhairi J. Maxwell,
Alex Agrotis,
Jack R. Jerome,
Emily M. Hargreaves,
Steven Gerondakis,
Margaret L. Hibbs,
Fabienne Mackay,
Jennifer L. Wilkinson-Berka

Affiliations

Devy Deliyanti: Department of Diabetes, The Central Clinical School, Monash University
Dean M. Talia: Department of Diabetes, The Central Clinical School, Monash University
Tong Zhu: Department of Diabetes, The Central Clinical School, Monash University
Mhairi J. Maxwell: Department of Immunology and Pathology, The Central Clinical School, Monash University
Alex Agrotis: Department of Diabetes, The Central Clinical School, Monash University
Jack R. Jerome: Department of Diabetes, The Central Clinical School, Monash University
Emily M. Hargreaves: Department of Diabetes, The Central Clinical School, Monash University
Steven Gerondakis: Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
Margaret L. Hibbs: Department of Immunology and Pathology, The Central Clinical School, Monash University
Fabienne Mackay: School of Biomedical Sciences, The University of Melbourne
Jennifer L. Wilkinson-Berka: Department of Diabetes, The Central Clinical School, Monash University

DOI: https://doi.org/10.1038/s41467-017-00751-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that interventions that augment the retinal Treg numbers reduce neovascular retinopathy in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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