Sensitive Electrochemical Sensors for Glucose Detection Based on Ni(OH)2/Nickel-Dimethylglyoxime Composite Nanotubes

Abstract

Eectrochemical glucose sensors is crucial for both environmental and human health, requiring rational nanoarchitectures with high electrochemical performance for glucose oxidation. Ni(OH)2/Ni(DMG)2 composite nanotubes were synthesized by etching nickel-dimethylglyoxime (DMG) nanorods with OH−, using Ni(DMG)2 as a partially sacrificial template. The optimal Ni(OH)2/Ni(DMG)2 nonenzymatic glucose sensor was evaluated on both conventional and portable electrochemical workstations, showing high sensitivity and a low detection limit. The optimal Ni(OH)2/Ni(DMG)2 glucose sensors integrated into smartphones demonstrated a low detection limit of 3.3 µM (M = mol L−1), a wide linear range (10 µM–8 mM), and a sensitivity of 262.80 µA mM−1 cm−2 for glucose detection. The sensors also exhibited favorable stability and reproducibility, along with preferable resistance to interference in the presence of uric acid, gluconate, proline, NaCl, valine, and lysine. Moreover, the portable sensor also demonstrated satisfactory glucose recovery (97.25–104 %) in serum samples, indicating its potential for future applications in real samples analysis.

Keywords

• electrochemical sensor
• glucose detection
• nonenzymatic
• nanotubes