SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Tyler D. R. Vance; Patrick Yip; Elisabet Jiménez; Sheng Li; Diana Gawol; James Byrnes; Isabel Usón; Ahmed Ziyyat; Jeffrey E. Lee

doi:10.1038/s42003-022-03883-y

Communications Biology (Sep 2022)

SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Tyler D. R. Vance,
Patrick Yip,
Elisabet Jiménez,
Sheng Li,
Diana Gawol,
James Byrnes,
Isabel Usón,
Ahmed Ziyyat,
Jeffrey E. Lee

Affiliations

Tyler D. R. Vance: Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto
Patrick Yip: Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto
Elisabet Jiménez: Institute of Molecular Biology of Barcelona (IBMB-CSIC)
Sheng Li: Department of Medicine, University of California San Diego
Diana Gawol: Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto
James Byrnes: National Synchrotron Light Source II, Brookhaven National Laboratory
Isabel Usón: Institute of Molecular Biology of Barcelona (IBMB-CSIC)
Ahmed Ziyyat: Université Paris Cité, CNRS, INSERM, Institut Cochin
Jeffrey E. Lee: Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto

DOI: https://doi.org/10.1038/s42003-022-03883-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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The crystal structure of sperm-expressed surface protein SPACA6 shows similarities to IZUMO1 though their functions are not redundant. Structural homology search in the AlphaFold human proteome and sequence search suggest a superfamily of mammalian gamete fusion-associated proteins.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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