Recurrent spontaneous miscarriage: controversies in etiology and pathogenesis

Abstract

Aim. We have studied and analyzed the available scientific sources over the past five years in order to systematize the available literature of recent years about research regarding recurrent spontaneous miscarriage. Methods. During this studying we used methods of observation, systematization and content analysis. Results. Modern views on etiology and pathogenesis of recurrent spontaneous miscarriage, in particular were presented in the article. Attention is focused on risk factors such as genetic disorders, anatomical abnormalities, endocrine pathology, infectious agents, autoimmune and immune disorders. Conclusions. Our research iindicated role of progesterone and highlighted importance of genetic polymorphisms in the etiology and pathogenesis of recurrent spontaneous miscarriage.

Keywords

• Abortion Habitual
• Genetic Polymorphism
• Progesterone Receptors