Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry
Baiba Svalbe,
Solveiga Grinberga,
Gundega Stelfa,
Edijs Vavers,
Baiba Zvejniece,
Eduards Sevostjanovs,
Maija Dambrova,
Liga Zvejniece
Affiliations
Baiba Svalbe
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia; Corresponding author.
Solveiga Grinberga
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia
Gundega Stelfa
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia; Latvia University of Life Sciences and Technologies, K.Helmana 8, Jelgava, LV-3004, Latvia
Edijs Vavers
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia; Riga Stradins University, Dzirciema 16, Riga, LV-1007, Latvia
Baiba Zvejniece
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia
Eduards Sevostjanovs
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia
Maija Dambrova
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia; Riga Stradins University, Dzirciema 16, Riga, LV-1007, Latvia
Liga Zvejniece
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia
MK-801, a N-methyl-d-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1]. Keywords: i.p. and s.c. administration route, MK-801, Bioavailability, Mice, UPLC-MS/MS
