Use of vasopressors in patients with acute kidney injury on continuous kidney replacement therapy.

Abstract

ObjectiveTo investigate whether the use of a specific vasopressor was associated with increased mortality or adverse outcomes in patients with acute kidney injury (AKI) receiving continuous kidney replacement therapy (CKRT).MethodsPatients with AKI who underwent CKRT between 1/1/2012-1/1/2021 at a tertiary academic hospital were included. Cox proportional hazard model was used to assess the relationship between time-dependent vasopressor dose and in-hospital mortality.ResultsThere were 641 patients with AKI that required CKRT. In-hospital mortality occurred in 318 (49.6%) patients. Those who died were older (63 vs 57 years), had higher SOFA score (10.6 vs 9) and lactate (6 vs 3.3 mmol/L). In multivariable model, increasing doses of norepinephrine [HR 4.4 (95% CI: 2.3-7, pConclusionThe associations between norepinephrine and vasopressin with in-hospital mortality could be related to their common use in this cohort.