Renal function and morning surge rate of systolic blood pressure in young hypertensive men aged under 35 years

Abstract

Aim. To investigate the link between renal function and morning surge rate (MSR) of systolic blood pressure (SBP) in young men with arterial hypertension (AH), aged under 35 years.Material and methods. The study included 58 young men with essential AH, aged 18-35 years (mean AH duration 4+1,5 years). Twenty-four-hour BP monitoring (BPM), dynamic angionephroscintigraphy with DTPA 99mTc, and 24-hour microalbuminuria assessment were performed in all participants.Results. In patients with normal SBP MSR, mean total glomerular filtration rate (GFR) was 151,6+38,9, among patients with elevated SBP MSR - 125,4+36,9 (p=0,06). Among those with normal SBP MSR, mean total GFR was 140,4+34,7 in Stage II AH, and 190,5+28,9 in Stage III AH (p=0,07). Among subjects with elevated SBP MSR, mean total GFR was 174+27,2, 117,2+33,1 (p=0,01), and 125,5+37,1 in Stage I, II, and III AH, respectively.Conclusion. AH progression was associated with higher prevalence of elevated SBP MSR. For AH patients with normal SBP MSR, hyperfiltration was more typical, while subjects with elevated SBP MSR were characterized by progressively decreasing total GFR, from hyperfiltration to normofiltration

Keywords

• young patients
• essential arterial hypertension
• 24-hour blood pressure monitoring
• morning surge rate of systolic blood pressure
• total glomerular filtration rate
• microalbuminuria