Molecular Analysis of Caprine Enterovirus Circulating in China during 2016–2021: Evolutionary Significance

Xiaoran Chang; Qian Lin; Qun Zhang; Junying Hu; Gulbahar Tursun; Yingrui Deng; Chunguang Guo; Xinping Wang

doi:10.3390/v14051051

Viruses (May 2022)

Molecular Analysis of Caprine Enterovirus Circulating in China during 2016–2021: Evolutionary Significance

Xiaoran Chang,
Qian Lin,
Qun Zhang,
Junying Hu,
Gulbahar Tursun,
Yingrui Deng,
Chunguang Guo,
Xinping Wang

Affiliations

Xiaoran Chang: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Qian Lin: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Qun Zhang: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Junying Hu: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Gulbahar Tursun: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Yingrui Deng: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Chunguang Guo: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China
Xinping Wang: State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China

DOI: https://doi.org/10.3390/v14051051
Journal volume & issue: Vol. 14, no. 5
p. 1051

Abstract

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Here, we report the characterization of 13 novel caprine/ovine enterovirus strains isolated from different regions in China during 2016–2021. Immunoperoxidase monolayer assay showed that these viral strains shared strong cross-reaction with the previously reported caprine enterovirus CEV-JL14. Alignment analysis of the complete nucleotide sequences revealed 79.2%–87.8% and 75.0%–76.7% sequence identity of these novel caprine enterovirus strains to CEV-JL14 and TB4-OEV, respectively. Phylogenetic analyses clustered these novel strains to EV-G based on the amino acid sequences of P1 and 2C+3CD. Moreover, phylogenetic analysis of these caprine enterovirus strains identified three new EV-G types using VP1 sequences. These results demonstrate the genetic variations and the evolution of caprine enterovirus.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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