Nature Communications (Nov 2022)

Structural insights into the contactin 1 – neurofascin 155 adhesion complex

  • Lucas M. P. Chataigner,
  • Christos Gogou,
  • Maurits A. den Boer,
  • Cátia P. Frias,
  • Dominique M. E. Thies-Weesie,
  • Joke C. M. Granneman,
  • Albert J. R. Heck,
  • Dimphna H. Meijer,
  • Bert J. C. Janssen

DOI
https://doi.org/10.1038/s41467-022-34302-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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In this work the authors show how a combination of glycosylations, rigid and flexible parts within neurofascin 155 and contactin 1 define a 7.4 nm distance at the myelin-axon interface and allow bridging of three-fold larger distances in the synapse.