Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion

• Sanghee Park,
• Il-Young Kim,
• Byong-Sop Song,
• Ji Sun Moon,
• Jingwen Tian,
• Ho Yeop Lee,
• Byeong Chang Sim,
• Seok-Hwan Kim,
• Seul Gi Kang,
• Jung Tae Kim,
• Ha Thi Nga,
• Rui Benfeitas,
• Yeongmin Kim,
• Robert R. Wolfe,
• Hyuk Soo Eun,
• Minho Shong,
• Sunjae Lee,
• Hyon-Seung Yi

Affiliations

Sanghee Park

1 Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Il-Young Kim

2 Department of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine, Incheon, Republic of Korea

Byong-Sop Song

Department of Core Laboratory of Translational Research, Biomedical Convergence Research Center, Chungnam National University Hospital, Daejeon, South Korea

Ji Sun Moon

Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, South Korea

Jingwen Tian

Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, South Korea

Ho Yeop Lee

Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, South Korea

Byeong Chang Sim

Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, South Korea

Seok-Hwan Kim

Department of Surgery, Chungnam National University School of Medicine, Daejeon, South Korea

Seul Gi Kang

Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea

Jung Tae Kim

Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea

Ha Thi Nga

Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, South Korea

Rui Benfeitas

National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Stockholm, Sweden

Yeongmin Kim

Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences & Technology (GAIHST), Incheon, South Korea

Robert R. Wolfe

Department of Geriatrics, the Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Hyuk Soo Eun

Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea

Minho Shong

Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea

Sunjae Lee

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea

Hyon-Seung Yi

Department of Core Laboratory of Translational Research, Biomedical Convergence Research Center, Chungnam National University Hospital, Daejeon, South Korea