Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study
Brieg Dissaux,
Doria Mazouz Fatmi,
Julien Ognard,
Bastien Allard,
Nathalie Keromnes,
Amina Latreche,
Amandine Lepeuve,
Ulrike Schick,
Vincent Bourbonne,
Douraied Ben Salem,
Gurvan Dissaux,
Solène Querellou
Affiliations
Brieg Dissaux
Radiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Doria Mazouz Fatmi
Radiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Julien Ognard
Radiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Bastien Allard
Nuclear Medicine Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Nathalie Keromnes
Nuclear Medicine Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Amina Latreche
Radiation Oncology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Amandine Lepeuve
UFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, France
Ulrike Schick
UFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, France
Vincent Bourbonne
UFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, France
Douraied Ben Salem
Radiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Gurvan Dissaux
UFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, France
Solène Querellou
Groupe d’Étude de la Thrombose Occidentale GETBO (Inserm UMR 1304), Université de Bretagne Occidentale, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, France
Background: The aim of this prospective monocentric study was to assess the inter-observer agreement for tumor volume delineations by multiparametric MRI and 18-F-FET-PET/CT in newly diagnosed, untreated high-grade glioma (HGG) patients. Methods: Thirty patients HGG underwent O-(2-[18F]-fluoroethyl)-l-tyrosine(18F-FET) positron emission tomography (PET), and multiparametric MRI with computation of rCBV map and K2 map. Three nuclear physicians and three radiologists with different levels of experience delineated the 18-F-FET-PET/CT and 6 MRI sequences, respectively. Spatial similarity (Dice and Jaccard: DSC and JSC) and overlap (Overlap: OV) coefficients were calculated between the readers for each sequence. Results: DSC, JSC, and OV were high for 18F-FET PET/CT, T1-GD, and T2-FLAIR (>0.67). The Spearman correlation coefficient between readers was ≥0.6 for these sequences. Cross-comparison of similarity and overlap parameters showed significant differences for DSC and JSC between 18F-FET PET/CT and T2-FLAIR and for JSC between 18F-FET PET/CT and T1-GD with higher values for 18F-FET PET/CT. No significant difference was found between T1-GD and T2-FLAIR. rCBV, K2, b1000, and ADC showed correlation coefficients between readers <0.6. Conclusion: The interobserver agreements for tumor volume delineations were high for 18-F-FET-PET/CT, T1-GD, and T2-FLAIR. The DWI (b1000, ADC), rCBV, and K2-based sequences, as performed, did not seem sufficiently reproducible to be used in daily practice.
