Nature Communications (Jun 2016)

In vivo imaging of clock gene expression in multiple tissues of freely moving mice

  • Toshiyuki Hamada,
  • Kenneth Sutherland,
  • Masayori Ishikawa,
  • Naoki Miyamoto,
  • Sato Honma,
  • Hiroki Shirato,
  • Ken-ichi Honma

DOI
https://doi.org/10.1038/ncomms11705
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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The circadian rhythms of peripheral clocks are difficult to study. Here the authors demonstrate a technique to image clock gene expression simultaneously in various tissues of freely moving mice, and use it to show that a long duration light pulse resets the rhythms in the olfactory bulb faster than other tissues.