Nature Communications (Jan 2019)
Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells
- Jiangping He,
- Xiuling Fu,
- Meng Zhang,
- Fangfang He,
- Wenjuan Li,
- Mazid Md. Abdul,
- Jianguo Zhou,
- Li Sun,
- Chen Chang,
- Yuhao Li,
- He Liu,
- Kaixin Wu,
- Isaac A. Babarinde,
- Qiang Zhuang,
- Yuin-Han Loh,
- Jiekai Chen,
- Miguel A. Esteban,
- Andrew P. Hutchins
Affiliations
- Jiangping He
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xiuling Fu
- Department of Biology, Southern University of Science and Technology
- Meng Zhang
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Fangfang He
- Department of Biology, Southern University of Science and Technology
- Wenjuan Li
- Joint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Mazid Md. Abdul
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Jianguo Zhou
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Li Sun
- Department of Biology, Southern University of Science and Technology
- Chen Chang
- Department of Biology, Southern University of Science and Technology
- Yuhao Li
- Department of Biology, Southern University of Science and Technology
- He Liu
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Kaixin Wu
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Isaac A. Babarinde
- Department of Biology, Southern University of Science and Technology
- Qiang Zhuang
- Department of Biology, Southern University of Science and Technology
- Yuin-Han Loh
- Epigenetics and Cell Fates Laboratory, A*STAR Institute of Molecular and Cell Biology
- Jiekai Chen
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Miguel A. Esteban
- Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Andrew P. Hutchins
- Department of Biology, Southern University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-018-08006-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Transposable elements (TEs) fulfill essential but poorly understood roles in genome organization and gene expression control. Here the authors show that the regulation of TEs occurs through overlapping epigenetic mechanisms that control the expression and chromatin signatures at TEs.
