Nature Communications (Apr 2019)
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
- Tim van Groningen,
- Nurdan Akogul,
- Ellen M. Westerhout,
- Alvin Chan,
- Nancy E. Hasselt,
- Danny A. Zwijnenburg,
- Marloes Broekmans,
- Peter Stroeken,
- Franciska Haneveld,
- Gerrit K. J. Hooijer,
- C. Dilara Savci-Heijink,
- Arjan Lakeman,
- Richard Volckmann,
- Peter van Sluis,
- Linda J. Valentijn,
- Jan Koster,
- Rogier Versteeg,
- Johan van Nes
Affiliations
- Tim van Groningen
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Nurdan Akogul
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Ellen M. Westerhout
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Alvin Chan
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Nancy E. Hasselt
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Danny A. Zwijnenburg
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Marloes Broekmans
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Peter Stroeken
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Franciska Haneveld
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Gerrit K. J. Hooijer
- Department of Pathology, Amsterdam UMC University of Amsterdam
- C. Dilara Savci-Heijink
- Department of Pathology, Amsterdam UMC University of Amsterdam
- Arjan Lakeman
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Richard Volckmann
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Peter van Sluis
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Linda J. Valentijn
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Jan Koster
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Rogier Versteeg
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- Johan van Nes
- Department of Oncogenomics, Amsterdam UMC University of Amsterdam
- DOI
- https://doi.org/10.1038/s41467-019-09470-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.
