Postexposure Treatment of Marburg Virus Infection

Abstract

Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus–based vaccine is administered 20–30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.

Keywords

• Marburg virus
• filovirus
• vesicular stomatitis virus
• vaccine
• treatment
• viruses