Synthesis and Characterization of Tetrachloro-1,3-Oxazepine Derivatives and Evaluation of Their Biological Activities

Abstract

6,7,8,9-Tetrachloro[1,3]oxazepine-1,5-dione derivatives 1b–10b have been synthesized by reacting Schiff bases 1a–10a with tetrachlorophthalic anhydride (TCPA) under (2 + 5 → 7) cycloaddition reaction conditons. All reactions had been monitored using TLC. FT IR and melting points have been used to characterize the Schiff bases; oxazepine compounds 1b–10b were characterized using FT IR, 1H NMR and their melting points. Biological activity for oxazepine compounds has been evaluated against bacterial types (Staphylococcus aureus, Escherichia coli, Klebsiella spp.) and against a fungus (Geotrichum spp.). Variable activities have been observed against used strains of bacteria and fungi.

Keywords

• oxazepine
• tetrachlorophthalic anhydride
• antibacterial
• antifungal