Frontiers in Molecular Biosciences (Jun 2024)
Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases
- Xiaobo Yang,
- Xiaobo Yang,
- Xiaobo Yang,
- Xiaobo Yang,
- Shaodian Zhang,
- Shaodian Zhang,
- Shaodian Zhang,
- Shaodian Zhang,
- Jinwei Lu,
- Jinwei Lu,
- Jinwei Lu,
- Jinwei Lu,
- Xiaoling Chen,
- Tian Zheng,
- Tian Zheng,
- Tian Zheng,
- Tian Zheng,
- Rongxin He,
- Rongxin He,
- Rongxin He,
- Rongxin He,
- Chenyi Ye,
- Chenyi Ye,
- Chenyi Ye,
- Chenyi Ye,
- Jianbin Xu,
- Jianbin Xu,
- Jianbin Xu,
- Jianbin Xu
Affiliations
- Xiaobo Yang
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Xiaobo Yang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Xiaobo Yang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Xiaobo Yang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- Shaodian Zhang
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Shaodian Zhang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Shaodian Zhang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Shaodian Zhang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- Jinwei Lu
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Jinwei Lu
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Jinwei Lu
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Jinwei Lu
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- Xiaoling Chen
- Department of Plastic Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China
- Tian Zheng
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Tian Zheng
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Tian Zheng
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Tian Zheng
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- Rongxin He
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Rongxin He
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Rongxin He
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Rongxin He
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- Chenyi Ye
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Chenyi Ye
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Chenyi Ye
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Chenyi Ye
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- Jianbin Xu
- Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Jianbin Xu
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Jianbin Xu
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Jianbin Xu
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China
- DOI
- https://doi.org/10.3389/fmolb.2024.1268019
- Journal volume & issue
-
Vol. 11
Abstract
Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective. Research has shifted from conventional therapies based on mesenchymal stem cells (MSCs) to exosomes derived from MSCs. Exosomes are natural nanocarriers of endogenous DNA, RNA, proteins, and lipids and have a low immune clearance rate and good barrier penetration and allow targeted delivery of therapeutics. MSC-derived exosomes (MSC-exosomes) have the characteristics of both MSCs and exosomes, and so they can have both immunosuppressive and tissue-regenerative effects. Despite advances in our knowledge of MSC-exosomes, their regulatory mechanisms and functionalities are unclear. Here we review the therapeutic potential of MSC-exosomes for skeletal diseases.
Keywords
