MSF-UBRW: An Improved Unbalanced Bi-Random Walk Method to Infer Human lncRNA-Disease Associations

Abstract

Long-non-coding RNA (lncRNA) is a transcription product that exerts its biological functions through a variety of mechanisms. The occurrence and development of a series of human diseases are closely related to abnormal expression levels of lncRNAs. Scientists have developed many computational models to identify the lncRNA-disease associations (LDAs). However, many potential LDAs are still unknown. In this paper, a novel method, namely MSF-UBRW (multiple similarities fusion based on unbalanced bi-random walk), is designed to explore new LDAs. First, two similarities (functional similarity and Gaussian Interaction Profile kernel similarity) of lncRNAs are calculated and fused linearly, also for disease data. Then, the known association matrix is preprocessed. Next, the linear neighbor similarities of lncRNAs and diseases are calculated, respectively. After that, the potential associations are predicted based on unbalanced bi-random walk. The fusion of multiple similarities improves the prediction performance of MSF-UBRW to a large extent. Finally, the prediction ability of the MSF-UBRW algorithm is measured by two statistical methods, leave-one-out cross-validation (LOOCV) and 5-fold cross-validation (5-fold CV). The AUCs of 0.9391 in LOOCV and 0.9183 (±0.0054) in 5-fold CV confirmed the reliable prediction ability of the MSF-UBRW method. Case studies of three common diseases also show that the MSF-UBRW method can infer new LDAs effectively.

Keywords

• lncRNA-disease associations
• linear neighborhood similarity
• Gaussian interaction profile
• logistic function
• unbalanced bi-random walk