Synthesis of 2-(6-Acetamidobenzothiazolethio)acetic Acid Esters as Photosynthesis Inhibitors

Abstract

The synthesis and photosynthesis-inhibiting activity of 13 new 2-(6-acetamidobenzothiazolethio)acetic acid esters are reported. The new compounds were prepared by acetylation of 2-(alkoxycarbonylmethylthio)-6-aminobenzothiazoles with acetic anhydride. The structure of the compounds was verified by 1H NMR spectra. The compounds inhibit photosynthetic electron transfer in spinach chloroplasts. The structure - activity relation was studied. Lipophilicity was found to influence substantially photosynthetic electron transfer.

Keywords

• Electron transfer inhibition
• QSAR
• lipophilicity