Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

Shrikant B. Kokate; Katarzyna Ciuba; Vivien D. Tran; Reena Kumari; Sari Tojkander; Ulrike Engel; Konstantin Kogan; Sanjay Kumar; Pekka Lappalainen

doi:10.1038/s41467-022-33688-w

Nature Communications (Oct 2022)

Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

Shrikant B. Kokate,
Katarzyna Ciuba,
Vivien D. Tran,
Reena Kumari,
Sari Tojkander,
Ulrike Engel,
Konstantin Kogan,
Sanjay Kumar,
Pekka Lappalainen

Affiliations

Shrikant B. Kokate: HiLIFE Institute of Biotechnology, University of Helsinki
Katarzyna Ciuba: HiLIFE Institute of Biotechnology, University of Helsinki
Vivien D. Tran: Department of Bioengineering, University of California
Reena Kumari: HiLIFE Institute of Biotechnology, University of Helsinki
Sari Tojkander: Faculty of Medicine and Health Technology, Tampere University
Ulrike Engel: Nikon Imaging Center at Heidelberg University and Centre for Organismal Studies (COS), Heidelberg University
Konstantin Kogan: HiLIFE Institute of Biotechnology, University of Helsinki
Sanjay Kumar: Department of Bioengineering, University of California
Pekka Lappalainen: HiLIFE Institute of Biotechnology, University of Helsinki

DOI: https://doi.org/10.1038/s41467-022-33688-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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In this study the authors report that Caldesmon controls force-balance and architecture of stress fibers through dynamic cross-linking of actin and myosin filaments. Caldesmon depletion led to consequent problems in cell morphogenesis, motility and mechanosensing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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