NON-PROTEINURIC DIABETIC KIDNEY DISEASE: CLINICAL MANIFESTATIONS, RENAL PROGNOSIS, AND MORTALITY - A NARRATIVE REVIEW.

Abstract

Background: Diabetic nephropathy (DN) is usually diagnosed by proteinuria before renal function diminishes. Many people with type 1 and type 2 diabetes develop non-proteinuric diabetic kidney disease, which worsens kidney function without proteinuria. Non-proteinuric DKD is becoming more common, but data is scarce. Objective: The objective of this narrative review is to provide a comprehensive examination of non-proteinuric diabetic kidney disease. This review aims to outline the clinical and pathological characteristics of non-proteinuric DKD, investigate its implications for renal prognosis, and assess mortality rates among individuals affected by this specific condition. By synthesizing existing knowledge and research, this review seeks to enhance our understanding of non-proteinuric DKD. Summary of Narrative Review: Non-proteinuric DKD is a lesser-known form of diabetic nephropathy. It discusses the clinical and pathological aspects of this illness and its unique diagnosis and therapeutic issues. Non-proteinuric DKD renal prognosis and mortality rates are also examined in the review. This narrative review illuminates non-proteinuric DKD in diabetic nephropathy by providing a broad overview. Future Research: To improve early detection and treatment of non-proteinuric DKD, future research should focus on more accurate diagnostic markers and risk factors. Targeted therapeutics need to understand the processes and pathways that cause renal failure without proteinuria. Long-term outcomes and progression of non-proteinuric DKD must be examined in longitudinal studies to determine its natural history and best therapy. Clinical Practice and Policy Development: Clinical consequences of non-proteinuric DKD should be considered, especially in diabetics with unexplained renal function decreases. Clinical standards and treatment algorithms for this condition are needed to improve patient care. Policymakers should fund non-proteinuric DKD research and attempt to improve healthcare system detection and management. Public health policy should educate doctors and diabetics to promote early intervention and better outcomes.

Keywords

• Non-proteinuric
• Diabetic Kidney Disease
• Renal function
• Clinical features
• Pathological features
• Mortality rates