The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids

Abstract

The effect of sequence polymorphisms on recombination is not fully understood. Here, the authors develop the seed-typing method to map crossovers (COs) by sequencing and show that COs occur preferentially within polymorphic hotspots and that this effect depends on the mismatch repair gene MSH2 in Arabidopsis.