8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

William D. Dupont; Joan P. Breyer; W. Dale Plummer; Sam S. Chang; Michael S. Cookson; Joseph A. Smith; University of Washington Center for Mendelian Genomics; Elizabeth E. Blue; Michael J. Bamshad; Jeffrey R. Smith

doi:10.1038/s41467-020-15122-1

Nature Communications (Mar 2020)

8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

William D. Dupont,
Joan P. Breyer,
W. Dale Plummer,
Sam S. Chang,
Michael S. Cookson,
Joseph A. Smith,
University of Washington Center for Mendelian Genomics,
Elizabeth E. Blue,
Michael J. Bamshad,
Jeffrey R. Smith

Affiliations

William D. Dupont: Department of Biostatistics, Vanderbilt University Medical Center
Joan P. Breyer: Department of Medicine, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, and Vanderbilt Genetics Institute, Vanderbilt University Medical Center
W. Dale Plummer: Department of Biostatistics, Vanderbilt University Medical Center
Sam S. Chang: Department of Urology, Vanderbilt University Medical Center
Michael S. Cookson: Department of Urology, University of Oklahoma Health Sciences Center
Joseph A. Smith: Department of Urology, Vanderbilt University Medical Center
University of Washington Center for Mendelian Genomics
Elizabeth E. Blue: Department of Medicine, Division of Medical Genetics, University of Washington, HSB H132
Michael J. Bamshad: Department of Pediatrics, Division of Genetic Medicine, and Center for Mendelian Genomics, University of Washington, HSB RR349
Jeffrey R. Smith: Department of Medicine, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, and Vanderbilt Genetics Institute, Vanderbilt University Medical Center

DOI: https://doi.org/10.1038/s41467-020-15122-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Inherited alterations of the 8q24 genomic locus are linked to cancer etiology. Here, the authors investigate hereditary prostate cancer to reveal ancestral risk-altering haplotypes, the sentinel genetic variants optimally predicting risk, and causal mutation candidates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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