Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

Laura M. Desrochers; François Bordeleau; Cynthia A. Reinhart-King; Richard A. Cerione; Marc A. Antonyak

doi:10.1038/ncomms11958

Nature Communications (Jun 2016)

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

Laura M. Desrochers,
François Bordeleau,
Cynthia A. Reinhart-King,
Richard A. Cerione,
Marc A. Antonyak

Affiliations

Laura M. Desrochers: Department of Molecular Medicine, Cornell University
François Bordeleau: Meinig School of Biomedical Engineering, Cornell University
Cynthia A. Reinhart-King: Meinig School of Biomedical Engineering, Cornell University
Richard A. Cerione: Department of Molecular Medicine, Cornell University
Marc A. Antonyak: Department of Molecular Medicine, Cornell University

DOI: https://doi.org/10.1038/ncomms11958
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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It is unclear how embryonic stem cells (ESC) communicate with surrounding cells during implantation. Here, the authors show that microvesicles (MV) are shed from ESCs, activating integrin and JNK/FAK kinases in trophoblasts, stimulating migration in vitro, and injecting MVs enhances blastocyst implantation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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