A nanotrap improves survival in severe sepsis by attenuating hyperinflammation

Changying Shi; Xiaojing Wang; Lili Wang; Qinghe Meng; Dandan Guo; Li Chen; Matthew Dai; Guirong Wang; Robert Cooney; Juntao Luo

doi:10.1038/s41467-020-17153-0

Nature Communications (Jul 2020)

A nanotrap improves survival in severe sepsis by attenuating hyperinflammation

Changying Shi,
Xiaojing Wang,
Lili Wang,
Qinghe Meng,
Dandan Guo,
Li Chen,
Matthew Dai,
Guirong Wang,
Robert Cooney,
Juntao Luo

Affiliations

Changying Shi: Department of Pharmacology, State University of New York Upstate Medical University
Xiaojing Wang: Department of Pharmacology, State University of New York Upstate Medical University
Lili Wang: Department of Pharmacology, State University of New York Upstate Medical University
Qinghe Meng: Department of Surgery, State University of New York Upstate Medical University
Dandan Guo: Department of Pharmacology, State University of New York Upstate Medical University
Li Chen: Department of Pathology, Baylor Scott and White Medical Center
Matthew Dai: Department of Pharmacology, State University of New York Upstate Medical University
Guirong Wang: Department of Surgery, State University of New York Upstate Medical University
Robert Cooney: Department of Surgery, State University of New York Upstate Medical University
Juntao Luo: Department of Pharmacology, State University of New York Upstate Medical University

DOI: https://doi.org/10.1038/s41467-020-17153-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Sepsis is a difficult to treat condition. Here, the authors present a telodendrimer nanotrap that captures inflammator mediators to improve survival in combination with antibiotic treatment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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