Biology of Sex Differences (Mar 2023)
Effects of 5α-dihydrotestosterone on the modulation of monocyte/macrophage response to Staphylococcus aureus: an in vitro study
- Déborah Cruz Dos Santos,
- Rafaela de Souza Bittencout,
- Iago Dórea Arêas,
- Larissa Silva C. Pena,
- Carolline Florentino Almeida,
- Bruna Carolina de Brito Guimarães,
- Rafael Santos Dantas Miranda Dórea,
- Thiago Macêdo Lopes Correia,
- Manoel Neres Santos Júnior,
- Lorena Lôbo Brito Morbeck,
- Talita Costa Dos Santos,
- Clarissa Leal S. Souza,
- Samira Itana de Souza,
- Telma de Jesus Soares,
- Regiane Yatsuda,
- Guilherme Barreto Campos,
- Lucas Miranda Marques
Affiliations
- Déborah Cruz Dos Santos
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Rafaela de Souza Bittencout
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Iago Dórea Arêas
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Larissa Silva C. Pena
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Carolline Florentino Almeida
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Bruna Carolina de Brito Guimarães
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Rafael Santos Dantas Miranda Dórea
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Thiago Macêdo Lopes Correia
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Manoel Neres Santos Júnior
- University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade
- Lorena Lôbo Brito Morbeck
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Talita Costa Dos Santos
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Clarissa Leal S. Souza
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Samira Itana de Souza
- Federal University of Bahia (UFBA)
- Telma de Jesus Soares
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Regiane Yatsuda
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Guilherme Barreto Campos
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- Lucas Miranda Marques
- Multidisciplinary Institute of Health, Federal University of Bahia (UFBA)
- DOI
- https://doi.org/10.1186/s13293-023-00501-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Highlights A sex difference in the immune response to S. aureus was observed. DHT stimulated a greater release of inflammatory cytokines. DHT promoted the activation of genes involved in this response. DHT suppressed the release of inflammatory markers.
Keywords
